The Haemonchus contortus kinome - a resource for fundamental molecular investigations and drug discovery
نویسندگان
چکیده
منابع مشابه
An In Vitro Test for Drug Resistance in Haemonchus contortus
A cambendazole-resistant (CR) strain of Haemonchus contortus, the large stomach nematode of sheep, had similar in vitro growth characteristics compared to the parent strain (BPL). When the in vitro cultivation system was modified to detect drug resistance: (1) exsheathed infective larvae of the BPL strain did not develop in a culture medium with a concentration of 2.5 /ug/rnl thiabendazole (TBZ...
متن کاملImmunological responses of sheep to Haemonchus contortus.
Infections with Haemonchus contortus are a major constraint on ruminant health world-wide. Young lambs are very sensitive to Haemonchus infection. Older lambs and sheep acquire immunity after a continuous or seasonal exposure to the parasite. The mechanisms underlying immunity are still not completely understood. Antibodies, in particular local IgA and IgE, certainly play a role. The role of Ig...
متن کاملHistological study on the ovaries of Haemonchus contortus (Nematoda)
Copyright: © 2017 | Author (s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made. The didelphic female reproductive system in Haemonchus contortus possesses telogo...
متن کاملSelection for anthelmintic resistance by macrocyclic lactones in Haemonchus contortus.
Two morphologically marked strains of Haemonchus contortus, CAVRS (smooth-macrocyclic lactone resistant) and McMaster (linguiform-macrocyclic lactone susceptible), were used to investigate the selection for anthelmintic resistance following exposure to ivermectin (IVM), a non-persistent anthelmintic. and a more persistent anthelmintic, oral moxidectin (MOX). Three types of selection were invest...
متن کاملThe cytochrome P450 family in the parasitic nematode Haemonchus contortus
Haemonchus contortus, a highly pathogenic and economically important parasitic nematode of sheep, is particularly adept at developing resistance to the anthelmintic drugs used in its treatment and control. The basis of anthelmintic resistance is poorly understood for many commonly used drugs with most research being focused on mechanisms involving drug targets or drug efflux. Altered or increas...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2015
ISSN: 1756-3305
DOI: 10.1186/s13071-015-1231-5